Enzyme LOCK and KEY model and the active site - Germanwings airplane LOCKED door

May 21, 2015

Let's look at another  blog post that provides some data.  Then we shall look at the atomic flowchart ....atomic level --> biochemistry level --> street level REALITY with huamn activities, expressions, and tragic signaling EVENTS.

 

 

In addition, we will cover the Germanwings LOCK and KEY enzyme tragedy.

Germanwings Flight 9525 - Wikipedia, the free encyclopedia

en.wikipedia.org/wiki/Germanwings_Flight_9525
Wikipedia

On 24 March 2015, the aircraft, an Airbus A320-200, crashed 100 kilometres (62 mi) northwest of Nice, in the French Alps, after a constant descent that began ...

 

The other  blog post ............

RD-blog-number-5658 by Herb Zinser reviews the living EARTH cell and the Darwinian selction of Michael Brown for the EARTH LAB enzyme kinetics ...... social engineering kinetics experiment in the St.Louis region .....  a city well known for their knowledge of the architecture of Nature's bio-hardware and bio-software systems.

 

The year 2014 event of  interest  is..

  1. Shooting of Michael Brown - Wikipedia, the free encyclopediaen.wikipedia.org/wiki/Shooting_of_Michael_Brown
    The shooting of Michael Brown occurred on August 9, 2014, in Ferguson, Missouri, a suburb of St. Louis. Brown, an 18-year-old black man, was fatally shot by Darren ...
  2. In year 2014, we perceive society and communities as living bodies. For example, a high school with 400 students has a student  body.   For Nature's system point of VIEW, this stduent body has a metabolism , and the English  department  code En  --> provides en --> enzyme  .. human communications structres that can read and write nouns  and verbs  ..thus allowing INTERNAL enzymes new opportunities and new formats in
    expression systems..

The THYroid gland  was a pioneer in this communications technology with the human brain VOID.. 
It managed to get the code words printed in the   BIBLE  -->
Thy LORD  the thyroid  gland   

Picture

 

 

 
For the experiment  ...Nature's INTELLECT and molecular engineers  first   reviewed  the SYMBOL MACHINE on enzyme kinetics.

 

Adrian John Brown - Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Adrian_John_Brown
Wikipedia
Adrian John Brown, FRS (27 Apr 1852 – 02 Jul 1919) was a British Professor of Malting and Brewing at the University of Birmingham and a pioneer in the study of enzyme kinetics. ... to Burton to work as a chemist in the brewing industry for the next twenty-five years. ... Soc. 81 (1902) 373–388; ^ Harden A (1 February 1920).

.

A BRIEF HISTORY OF ENZYME KINETICS - BIPbip.cnrs-mrs.fr/bip10/newbeer/laidler.pdf
by KJ Laidler - ‎Cited by 7 - ‎Related articles
no more than give a broad outline of the development of enzyme kinetics. To give a ... In 1892, however, the British chemist Adrian John Brown, found in a study of the rate of ...
Brown himself mentioned in his 1902 paper that the distinguished French chemist ... 


Brown himself mentioned in his 1902 paper
Brown himself mentioned in his 1902 paper

Brown himself mentioned in his 1902 paper --> information evolution to

 

Brown himself mentioned in his  2014  paper in ST.Louis, Missouri  
on the  geography state of MIssouri  and the

STATE of MIND - Missouri  ....  subset code
Miss = Management information social schemes

Brown himself mentioned in his 1902 paper
Brown himself mentioned in his 1902 paper ..... the 

More Mechanisms: A Model of Enzyme Kineticswww.biochem.arizona.edu/.../ENZYMES/M-M_ki...
University of Arizona
In 1902 the study of enzyme kinetics began with the work of Adrian Brown. ... catalyzed by the yeast enzyme invertase (now known as beta-fructofuranosidase).

catalyzed by the yeast enzyme invertase ...year 1902
 catalyzed by the yeast enzyme invertase  war in St.Louis.....
code 1902 .... permutation 9201

code 1902 .... .... mutation 9201

Michael Brown occurred on August 9, 2014, in Ferguson, Missouri

Picture

 

 

 
 
Picture

 

 

 
Canfield  Drive – Site of Mike Brown Shooting – Becomes ...www.thegatewaypundit.com/.../canfield-drive-site-of-mike-brown-shooti...
Nov 26, 2014 - In Ferguson, Missouri, the site on Canfield Drive where robber Michael Brown was shot dead by white police officer Darren Wilson is becoming ...
.

 

Thus we have a word /   noun /  CONCEPT .....   linkage  mechanism between year 1902 and  year 2014.

Year 1902 Brown and the beer brewing industry  --> year 2014 Brown

Fermentation---> Fer --> the Ferguson public communitry --> Ferguson pub ... berr pub inside their brain STATE of MIND  

Brewing and beer --> implies beer cans  --> Implies  Canfield Drive in Ferguson, MIssouri   and the death of
Alicia Reynolds (aluminum metal for beer cans)  in Culpepper, Virginia 

Picture

 

 

 
Picture

 

 

 
now...we have one additional piece of information .....   in the Darwin  selection  of  proper  noun EARTH LAB human specimen --> Michael Brown.

 

Michaelis–Menten kinetics - Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/MichaelisMenten_kinetics
Wikipedia
In biochemistry, MichaelisMenten kinetics is one of the best-known models of enzyme kinetics. It is named after German biochemist Leonor Michaelis and ...‎Lineweaver–Burk plot - ‎Enzyme kinetics - ‎Maud Menten - ‎Leonor Michaelis

Michaelis–Menten kinetics 
Michael  is  -->
information systems to MIS (Missouri)


Thus biochemist Leonor  Michaelis and Adrian Brown  ..... continue their existence in the world of concepts and symbols   ..... in the modern EARTH LAB  via    their  namesake Michael Brown IS -= Information systems in MIS --> Missouri.

 

Picture

 

 

 
Michael Brown Rob   Convenience Store, Stole Cigarillos ...www.ibtimes.com/michael-brown-robbed-c...
International Business Times
Nov 25, 2014 - The store where police say Michael Brown Jr. stole cigarillos minutes .... stating how he had an attorney and even said brown didn't rob him.
Picture

 

 

 
Reaction Rate.

 

To understand Michaelis-Menten Kinetics, we will use the general enzyme reaction scheme shown below, which includes the back reactions in addition  the forward reactions:

Picture

 

 

 
Picture

 

 

 
Substrate  complex  --> pointer to apartment complex
Picture

 

 

 
The ES complex is formed by combining enzyme E with substrate S at rate constant k1.
 The ES complex can either dissociate to form EF (free enzyme) and S, or form product P at rate constant k2 and k3, respectively. The velocity equation can be derived in either of the 2 methods that follow:
Picture

 

 

 

Product concentraion ...provided by the grocery store products in the convenience store.

Picture

 

 

 
The newspaper reporters known as LIne Weavers of bull-story explanations..

 

Lineweaver-Burk double reciprocal plot:

Picture

 

 

 
St. Louis Post-Dispatchwww.stltoday.com/
St. Louis Post‑Dispatch .....
Lines written by Lineweaver enzymes using the english language  
 

Internet home for the St. Louis Post-Dispatch, Suburban Journals, and St. Louis Best Bridal. Includes local and national news, sports, entertainment, events, and ...
St. Louis Post-Dispatch Orbit bio-physics 

St. Louis Post-Dispatch Obit 
St. Louis Post-Dispatch Obituaries -
St. Louis Post-Dispatch .........aries -

 

Daily Horoscope for Aries - Astrology.comwww.astrology.com/horoscope/daily/aries.html
Daily Horoscopes for all signs. Astrology.com provides over 30 combinations of free daily, weekly, monthly and yearly horoscopes in a variety of interests ...‎Aries - ‎Aries Moon-

- Legacy.comwww.legacy.com/obituaries/stltoday/
Legacy.com
St. Louis Post-Dispatch obituaries and Death Notices for St. Louis Missouri area .
Explore Life Stories, Offer Condolences & Send Flowers.

stream of con·scious·ness
nounPsychology
noun: stream of consciousness; plural noun: streams of consciousness; modifier noun: stream-of-consciousness
  1. a person's thoughts and conscious reactions to events,
    perceived  as  a continuous flow.

    The term was introduced by William James in his Principles of Psychology (1890).

    • a literary style in which a character's thoughts, feelings, and reactions are depicted in a continuous flow uninterrupted by objective description or conventional dialogue. James Joyce, Virginia Woolf, and Marcel Proust are among its notable early exponents.

Other examples of INTERNAL enzyme systems and their EXTERNAL messages and human agents are ...

 

picture - lock 11picture - lock 12

http://herb01.weebly.com/uploads/1/2/4/2/12420435/5306403_orig.png

In modern times ..... modern DEMOS of the lock and key model ......

--> Penn State University DEMO  

Penn State child sex abuse scandal - Wikipedia, the free ...

en.wikipedia.org/wiki/Penn_State_child_sex_abuse_scandal
Wikipedia

Jerry Sandusky's criminal trial began on June 11, 2012, at the Centre County ......

 

take appropriate action after the locker room incident
 
McQueary witnessed.

 

Other lock and key messages ....

Remembering   the   enzyme(ss)   message  

1988 Lockerbie Bombing - History Channel

www.history.com/.../remembering-the-1988-lockerbie-bombing
History

Dec 20, 2013 - More U.S. civilians died in the bombing of Pan Am Flight 103 over Lockerbie, Scotland, which took place 25 years ago from Saturday, than in 

Other enyzme LOCK and KEY signals ...

 

Lock and Key Hypothesis: Understanding Enzymes

https://blog.udemy.com/lock-and-key-hypothesis/

Jun 18, 2014 - The lock and key hypothesis helps explain some of

 
the ways that enzymes work.

 

http://herb02.weebly.com/uploads/1/2/4/2/12420435/3304145_orig.png

Germanwings plane crashes in France - CNN.com

www.cnn.com/2015/03/24/world/gallery/france-plane-crash/
CNN

Apr 4, 2015 - A Germanwings Airbus A320 plane carrying 150 people crashed in the foothills of the French Alps on Tuesday, March 24.

The mystery of flight 9525:

a locked door,    a silent pilot and a ...

www.theguardian.com › ... › Germanwings flight 4U9525
The Guardian

Mar 28, 2015 - When the Germanwings Airbus disappeared, Europe was united in grief. Then, as the troubling facts behind the crash emerged, the shock and ...

Lock-and-key model - Biology-Online Dictionary

www.biology-online.org/dictionary/Lock-and-key_model

Dec 10, 2008 - Definition. noun. A model for enzyme-substrate interaction suggesting that the enzyme and the substrate possess specific complementary ...

Below ..... enzymes(s)  messages and Nature's communications to humans are ignored 

http://herb01.weebly.com/uploads/1/2/4/2/12420435/2955454_orig.png

Now, let's look at the atomic flowchart suggested by the Michaelis-Menten  equation with  Adrian Brown of year 1902.

Using the periodic atomic table of element of life and thought  ...we known that atoms have mass  ...and thus can engage in mass communications  ......  that is atomic mass communication.

 

atom table 6

 

 

  1. Mass Communication | Newsflavor

  2. Mass communication: television, radio, film, press; the ...

    Mass communication: television, radio, ... Mass communication: television, radio, film, ...

    A history of atomic and molecular mass communication in The United States of America.

    At the atomic level we have the human agent --> Paul Adrian Dirac.

    HIs books and theories eventually become part of the SYMBOL MACHINE and the Tree of Knowledge.

    Nature's SYMBOL MACHINE is comprised of  nouns, verbs, concepts, math equations,  flowcharts, etc.  The ideas found in math and science textbooks are part of the SYMBOL MACHINE.
     

    Maps and Territories - Rijnlandmodel

     

    Language in Thought and Action, S.I. Hayakawa.
    Chapter 2 Symbols Maps and Territories

    There is a sense in which we all live in two worlds.

    Eventually,  this knowledge goes from the conscious level of atomic physics class and LAB .... DOWN thru the human subconsicous levels to the Carl Jung atomic collective unconsciousness GIVING the periodic atomic table  consciousness.

    Thus we see a feedback system.

    The orginial periodic table thoughts and speculations   are sent UP to the conscious  level for experimental verification,  math models and  practicla applications ...... and those EARTH surface level experiences  then  are feedback to the periodic atomic table thought system.


    https://sites.google.com/a/zinoproject.com/z008---herb-zinser-science/_/rsrc/1425184290989/biochemistry-war/mitochondria-wars/theuwmmitochondriaandadenosinetriphosphatedeathsignalviatheharoonkhan/Civil%20war%20feedback%20control.PNG

    Thus ...we have year 1902

     

    Kinetics of Enzyme Action: Essential Principles for Drug ...

    https://books.google.com/books?isbn=1118084403
    Ross L. Stein - 2011 - ‎Science

    These concepts concerning mandatory formation of enzyme : substrate complexes were tied to the kinetic behavior of enzymes by Adrian Brown. In his 1902 ...Brown proposes

    "that one molecule of an enzyme combines with one molecule of a reacting substance, alipd that the compound ...

     

    Thus in year 1901/ 1902 in the EARTH LAB  geography  country of enGLAND   ........  in Bristol ..... 

    Mr and Mrs. Dirac (representing 2 molecules  combined   ..... in a bedroom reaction site)  ...... the result of that enzyme kinetic expression --> the year 1902 atomic agent was born ...... Adrian --> Adrien

    Paul Adrien Maurice Dirac was born at his parents' home in Bristol, England, on 8 August 1902,[5] and grew up in the Bishopston area of the city

    Thus Paul Adrien Maurice Dirac had primordial links to  enzyme activity ............. thus his later wiork in atomic foundations  .. that then provided an atomic foundation LINK for enzyme molecules.

    Thus ..we see   the sequence  ..  enyzmes in 1902  ..are looking forward (beer fermentaion work of Adian Brown)  and are looking back at their enzyme orgins (the atomic level).

    Thus in year 1902 ..... the enzymes began  working on the HIERARCHY PROBLEM of enyzmes.

    In hindsight .. we now see the sequence  .... after the adjustment in year 1902

    Paul Adrien Maurice Dirac (bor in year 1902)  thus provides the SYMBOL MACHINE with proper noun LINKAGE  maps and approximations.

    Adrein year 1902 --> information poineter to Adrain Brown and his year 1902 enzyme kinetics ..... and the fetus of Paul experienced those kinetics and experienced  Brownian motion  .. as the fetus left the womb and worked its way out thru the birth canal to the EXTERNAL world.  Thus the fetus Paul was left with impressive  experiences IMPRINTED into his subconscious mind  ..  and those experience later desired to learn the languages associated with those birth IMPRINTS.
    So impressed was his subconscious  mind  .....  that is gave birth to new ideas about existence.

    Maurice Dirac ---> information pointer to DNA and Maurice Wilkins.

     

  3. Maurice Wilkins: Behind the Scenes of DNA | Learn Science ...

    www.nature.com/.../maurice-wilkins-behind-the-scenes-of-dna-65...

     

     

     

     

     
    Nature

    Although Maurice Wilkins shared the 1962 Nobel Prize in physiology or medicine ... is not as commonly known as one of the discoverers of the structure of DNA.

  4. Maurice Wilkins - Wikipedia, the free encyclopedia

    en.wikipedia.org/wiki/Maurice_Wilkins

     

     

     

     

     
    Wikipedia

    Jump to DNA Phase two 1951–52 - By November 1951 Wilkins had evidence that DNAin cells as well as purified DNA had a helical structure. Alex Stokes  ...

     

  5. Maurice Wilkins - NZEdge.com

    www.nzedge.com/maurice-wilkins/

     

     

     

     

     

    Research undertaken by New Zealander Maurice Wilkins helped lead to the discovery of the DNA molecule structure - the very essence of life itself.


    Research undertaken by New Zealander Maurice Wilkins
    Research undertaken by New Zealander Maurice Wilkins


    Research undertaken by New Zealander Maurice Wilkins
    Research undertaken by New Z --> atomic number LINK to Double-Helix agent Maurice Wilkins

  6.  

    https://sites.google.com/a/zinoproject.com/z008---herb-zinser-science/_/rsrc/1425184290989/biochemistry-war/mitochondria-wars/theuwmmitochondriaandadenosinetriphosphatedeathsignalviatheharoonkhan/Civil%20war%20feedback%20control.PNG

    Thus we see the emergence of  these message system projects of Nature    ...... arriving at the street level ..... with a message.

     

    1. Shooting of Michael Brown - Wikipedia, the free encyclopedia

      en.wikipedia.org/wiki/Shooting_of_Michael_Brown

       

       

       

       
      Wikipedia

      The shooting of Michael Brown occurred on August 9, 2014, in Ferguson, Missouri, a suburb of St. Louis. Brown, an 18-year-old black man, was fatally shot by ...

       

      Cigarillo - ‎Hands up, don't shoot - ‎List of killings by law - ‎Indictment

       

      brown police line

       

       

      Michaelis–Menten kinetics - Wikipedia, the free encyclopedia

      en.wikipedia.org/wiki/Michaelis–Menten_kinetics
      Wikipedia

      Michaelis–Menten saturation curve for an enzyme reaction showing the relation between the ... to [S] , the concentration of a substrate S. Its formula is given by.

       

    the concentration of a substrate S
    the concentration of a substrate S
    the concentration of a substrate Street --> Canfield Drive  substrate

     

    brown  street

     

     

    Timeline for a Body: 4 Hours in the Middle of a Ferguson ...

    www.nytimes.com/.../michael-brown-a-bodys-timel...
     
    The New York TimesAug 23, 2014 - A makeshift memorial for Michael Brown on the spot on a Ferguson, Mo., street where his body lay for about four hours after he was shot by a

    Nature's systems reason for the 4 Hour DEMO  ...is the language message

    alphabet letter --> A  B  C  D
    location ------------> 1  2   3  4

    Therefore  --> 4 Hours --> 4 H --> eqivalent to --> D H  --> Doulble Helix message...

    The next  enzyme SIGNAL ... 

    michael brown store inhibitor

    Thus the INTERNAL enzyme behavior code, inibition , etc  

    and the EXTERNAL behavior display  in IS region of MIS = MIssouri

     

    The Michaelis-Menton
    .................is --> information systems display in MISSouri   VIA
    .......Michael    ...... inhibited ???  competitive ????
    michael brown rob store narobi

    Thus we  see Nature's expression system and its EXTERNAL information displays on the EARTH geography surface with human display devices and human action figures.

    hayakawa-1abstarction_ladder_2_larger

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